Journal article
Kinetic modeling of pH-dependent oxidation of dopamine by iron and its relevance to Parkinson's disease
Y Sun, AN Pham, DJ Hare, TD Waite
Frontiers in Neuroscience | FRONTIERS MEDIA SA | Published : 2018
Abstract
Parkinson's disease is the second most common neurodegenerative disease. While age is the most significant risk factor, the exact cause of this disease and the most effective approaches to mitigation remain unclear. It has long been proposed that dopamine may play a role in the pathology of Parkinson's disease in view of its ability to generate both protein-modifying quinones such as aminochrome and reactive oxygen species, especially in the presence of pathological iron accumulation in the primary site of neuron loss. Given the clinically measured acidosis of post-mortem Parkinson's disease brain tissue, the interaction between dopamine and iron was investigated over a pH range of 7.4 to 6...
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors would like to acknowledge the Sydney Brain Bank for advice regarding the pH measurements of post-mortem brain tissue from patients with neurodegenerative disease. The Sydney Brain Bank is supported by The University of New South Wales and Neuroscience Research Australia. We also gratefully acknowledge the China Scholarship Council and the University of New South Wales for scholarship support to YYS; and the National Health and Medical Research Council's Career Development Fellowship (Industry) support to DJH (GNT1122981). Supplementary data associated with this article can be found in the online version.